Gestational diabetes & diabetes in pregnancy
Use of fasting plasma glucose to determine the approach for diagnosing gestational diabetes mellitus
Authors' conclusion
HAPO mothers whose GDM diagnosis would be missed were not at greater risk for adverse neonatal and childhood outcomes than mothers with FPG of 4.5-5.0 without GDM.
Study context
- Population
- HAPO participants with 75-g OGTT at 24–32 weeks' gestation; follow-up OGTTs in mothers and children and child adiposity
- Comparison
- Women with GDM and FPG ≤ 4.4 mmol/L (Group 2) vs women with FPG > 4.4 mmol/L and no GDM (Group 3)
- Primary endpoint
- GDM diagnoses missed by performing OGTTs only on women with screening FPG of 4.5-5.0 mmol/L
Methodological detailsretrospective GDM classification by IADPSG criteria
- Retrospective GDM classification by IADPSG criteria
Primary result
As reported in the abstract
Missed GDM diagnosis with this strategy
GDM diagnosis missed
14.7%
Further findings
Neonatal outcomes (birthweight, percent neonatal fat, sum of skinfolds, cord C-peptide >90th percentiles)
- Odds for neonatal outcomes in Groups 2 and 3 not different (ORs)
- 1.14 to 1.29
Maternal T2D and disorders of glucose metabolism at follow-up
- Odds for T2D in mothers higher in Group 2 (OR)
- 3.51
- Odds for disorders of glucose metabolism in mothers higher in Group 2 (OR)
- 2.57
Childhood impaired glucose tolerance or adiposity outcomes · follow-up
- Odds for childhood impaired glucose tolerance or adiposity outcomes not different for Groups 2 and 3
Original publication
Use of fasting plasma glucose to determine the approach for diagnosing gestational diabetes mellitus. Diabetes Res Clin Pract. Published 13 October 2023. doi:10.
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