Gestational diabetes & diabetes in pregnancy
Maternal Glycemia During Pregnancy and Child Lung Function: A Prospective Cohort Study
Authors' conclusion
Maternal hyperglycemia was negatively associated with lung function in children, particularly among girls. Further studies are warranted to elucidate the underlying mechanisms of this association and to explore potential interventions to mitigate its effects.
Study context
- Population
- Children aged 6 years whose mothers underwent a 75-g oral glucose tolerance test (OGTT) between 24 and 28 weeks of gestation
- Participants
- 889 children
- Exposure
- Maternal gestational diabetes mellitus (GDM) vs no GDM; maternal OGTT glucose values
- Outcome
- Childhood lung function outcomes
- Follow-up
- Age 6 years
Methodological detailsbirth cohort, multivariable regression adjusted for prenatal and postnatal factors
- Birth cohort
- Multivariable regression adjusted for prenatal and postnatal factors
Main finding
As reported in the abstract
Lung function z scores (FEV1, FVC, FEF25-75%) · 6 years
- Maternal GDM significantly reduced z scores of FEV1, forced vital capacity (FVC) and forced expiratory flow at 25-75% of FVC, more pronounced in female offspring
- Maternal 1- and 2-h post-OGTT glucose z scores and their sum, but not fasting glucose, inversely associated with several lung function measures
- No significant associations with FEV1/FVC
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Impaired lung function (FVC <85% of predicted) | 2.64 (1.10–5.85) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
Maternal Glycemia During Pregnancy and Child Lung Function: A Prospective Cohort Study. Diabetes Care. Published 4 September 2024. doi:10.
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