Gestational diabetes & diabetes in pregnancy
Risk of Neonatal Hypoglycemia in Infants of Mothers With Gestational Glucose Intolerance
Authors' conclusion
GGI is associated with increased risk of neonatal hypoglycemia. Future research should include examination of these associations in a cohort with more complete neonatal blood glucose ascertainment and determination of the clinical significance of these findings on long-term child health.
Study context
- Population
- Mother-infant dyads delivered at two hospitals, 2014–2023
- Participants
- 8,262 mother-infant dyads
- Comparison
- Maternal GGI-0, GGI-1 or GDM vs normal glucose tolerance (NGT)
- Primary endpoint
- Neonatal hypoglycemia (blood glucose <45 mg/dL or ICD-9/ICD-10 diagnosis)
Methodological detailstwo hospitals, logistic regression, sensitivity analysis using Δ-adjusted multiple imputation
- Two hospitals
- Logistic regression
- Sensitivity analysis using Δ-adjusted multiple imputation
Primary result
As reported in the abstract
Neonatal hypoglycemia
Each group vs NGTAdjusted odds ratio (95% CI)
GGI-0
1.28(1.12–1.65)
GGI-1
1.58(1.11–2.25)
GDM
4.90(3.81–6.29)
- Infants with neonatal hypoglycemia (all infants)
- 12%
Further findings
Sensitivity analysis (Δ-adjusted multiple imputation, assumed rate up to 33% in unscreened infants)
- Associations consistent with the primary analysis
Original publication
Risk of Neonatal Hypoglycemia in Infants of Mothers With Gestational Glucose Intolerance. Diabetes Care. Published 24 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →