Gestational diabetes & diabetes in pregnancy
Preconception HbA 1c Levels in Adolescents and Young Adults and Adverse Birth Outcomes
Main finding · Gestational diabetes at first birthResult — go to the resultAdjusted relative risk 2.21 95% CI 1.91–2.56Authors' conclusion
In this study of adolescents and young adults with at least 1 preconception HbA1c test, prediabetes was associated with increased likelihood of maternal cardiometabolic morbidity at first birth. Efforts to optimize cardiometabolic health before pregnancy may avert excess maternal risk.
Study context
- Population
- Birthing individuals aged 10 to 24 years with no history of diabetes and ≥1 preconception hemoglobin A1c (HbA1c) test, New York City, 2009–2017; mean (SD) age 22.10 (1.55) years
- Participants
- 14,302 individuals
- Exposure
- Preconception prediabetes vs normoglycemia
- Prediabetesn = 2,895
- No diabetesn = 11,407reference
- Outcome
- Gestational diabetes at first birth
- Follow-up
- First birth
Methodological detailslinked birth registry, hospital discharge and NYC A1C Registry data
- Linked birth registry, hospital discharge and NYC A1C Registry data
Main finding
As reported in the abstract
Adjusted relative risk
2.21
95% CI 1.91–2.56
Prediabetesvs No diabetes
aRR 2.21 (95% CI 1.91–2.56)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aRR (95% CI) | |
|---|---|---|
| Hypertensive disorder of pregnancy · first birth | 1.18 (1.03–1.35) | |
| Preterm delivery · first birth | 1.18 (1.02–1.37) | |
| 0.512Adjusted relative risk (log scale) |
Cesarean delivery · first birth
- aRR for cesarean delivery increased but not statistically significant
- aRR, 1.09; 95% CI, 0.99-1.20
Macrosomia · first birth
- aRR for macrosomia increased but not statistically significant
- aRR, 1.13; 95% CI, 0.93-1.37
Optimal HbA1c threshold to identify gestational diabetes
- Optimal HbA1c threshold (all)
- 5.6%
- Optimal HbA1c threshold, Hispanic individuals; did not vary by obesity status
- 5.5%
Original publication
Preconception HbA 1c Levels in Adolescents and Young Adults and Adverse Birth Outcomes. JAMA Netw Open. Published 3 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →