Gestational diabetes & diabetes in pregnancy
Gestational diabetes mellitus and development of intergenerational overall and subtypes of cardiovascular diseases: a systematic review and meta-analysis
Authors' conclusion
These findings underscore the heightened risk of developing various CVDs for mothers and offspring affected by GDM, emphasizing the importance of preventive measures even right after birth to mitigate the burden of CVDs in these populations.
Study context
- Population
- Mothers and offspring post-delivery; studies from PubMed, Embase, Web of Science and Scopus, January 1980–June 2024
- Participants
- 77,678,684 mothers38 studies
- Comparison
- Gestational diabetes mellitus (GDM) vs no GDM
- Outcome
- Overall CVD development post-delivery in mothers and offspring
Methodological detailsrandom-effects meta-analysis, predefined PROSPERO protocol, Newcastle-Ottawa Scale quality assessment
- Random-effects meta-analysis
- Predefined PROSPERO protocol
- Newcastle-Ottawa Scale quality assessment
Pooled result
As reported in the abstract
Overall cardiovascular diseases (CVDs) after delivery
GDM vs No GDMRelative risk (95% CI)
Mothers
1.46(1.34–1.59)
Offspring
1.23(1.05–1.45)
Further pooled results
CVD subtypes in mothers (cerebrovascular disease, coronary artery disease, HF, VTE)
- Mothers with history of GDM faced various risks of developing different CVD subtypes
- 20% to 2-fold
- Subgroup analysis
Original publication
Gestational diabetes mellitus and development of intergenerational overall and subtypes of cardiovascular diseases: a systematic review and meta-analysis. Cardiovasc Diabetol. Published 28 August 2024. doi:10.
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