Gestational diabetes & diabetes in pregnancy
Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children
Authors' conclusion
Intrauterine exposure to GDM was associated with higher food-cue induced hippocampal FC especially to reward processing regions. Future studies with longitudinal measurements are needed to clarify whether altered hippocampal FC may raise the risk of the development of metabolic diseases later in life.
Study context
- Population
- Children aged 7–11 years (53 females) undergoing an functional magnetic resonance imaging (fMRI) visual food cue task in the fasted state53 females
- Participants
- 90 children
- Exposure
- Children with vs without in utero gestational diabetes mellitus (GDM) exposure
- Outcome
- Hippocampal functional connectivity in response to food vs non-food cues
Methodological detailsfMRI visual food cue task, generalized psychophysiological interaction analysis, adjusted for age, sex and WHR
- fMRI visual food cue task
- Generalized psychophysiological interaction analysis
- Adjusted for age, sex and WHR
Main finding
As reported in the abstract
Hippocampal FC, high caloric food vs non-food cues
- Children with GDM exposure had higher hippocampal functional connectivity (FC) to the insula and striatum (putamen, pallidum and nucleus accumbens) vs unexposed children
Observational data: associations, not effects.
Further findings
Hippocampal FC by childhood BMI
- With increasing BMI, children with GDM exposure had lower hippocampal FC to the somatosensory cortex (postcentral gyrus)
Original publication
Exposure to gestational diabetes mellitus in utero impacts hippocampal functional connectivity in response to food cues in children. Int J Obes (Lond). Published 28 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →