Gestational diabetes & diabetes in pregnancy
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS‐CoV‐2 infection
Authors' conclusion
Exposure to maternal SARS-CoV-2 infection was associated with an increased risk of receiving a cardiometabolic diagnosis by 18 months preceded by greater BMI-for-age at 6 months.
Study context
- Population
- Live-born offspring of all individuals who delivered during the COVID-19 pandemic (April 1, 2020-December 31, 2021) at eight hospitals in Massachusetts
- Participants
- 29,510 offspring
- Exposure
- In utero exposure to maternal SARS-CoV-2 infection vs no exposure
- Exposedn = 1,599
- Unexposedn = 27,911reference
- Outcome
- ICD-10 code for a cardiometabolic disorder in offspring electronic health record (EHR)
- Follow-up
- By 18 months
Methodological detailselectronic health record-based, multicentre (eight hospitals)
- Electronic health record-based
- Multicentre (eight hospitals)
Main finding
As reported in the abstract
Cardiometabolic diagnosis
Each group vs unexposedEstimate (95% CI)P value
Exposed
crude OR 1.47(1.10–1.94)
P = 0.007Exposed
aOR 1.38(1.06–1.77)
P = 0.01Observational data: associations, not effects.
Further findings
| Outcome | Adjusted difference (95% CI) | P value | |
|---|---|---|---|
| Mean BMI-for-age z score · 6 monthsExposedvs Unexposed | 0.04 (−0.06 to 0.13) | P = 0.4 | |
| −0.100.10.2Difference (linear scale) |
| Outcome | Z score difference (95% CI) | P value |
|---|---|---|
| Mean BMI-for-age z score · 6 monthsExposed vs Unexposed · greater with Exposed | 0.19 (0.10–0.29) | P < 0.001 |
Original publication
Offspring cardiometabolic outcomes and postnatal growth trajectories after exposure to maternal SARS‐CoV‐2 infection. Obesity (Silver Spring). Published 13 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →