Gestational diabetes & diabetes in pregnancy
GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study
Authors' conclusion
GLP-1R polymorphisms modify the association between GDM and BMI growth among youth. Further studies are needed to replicate these findings, and to better understand the mechanisms by which GLP-1R polymorphisms lead to heterogeneity in offspring BMI growth.
Study context
- Population
- Youth from the EPOCH study, genotyped in childhood (∼10 years); BMI trajectories across childhood and adolescence; OGTT in adolescence (∼16 years)
- Participants
- 464 participants
- Exposure
- Gestational diabetes mellitus (GDM) exposure vs no exposure, by GLP-1R polymorphism genotype
- Outcome
- Effect modification by three GLP-1R polymorphisms of the associations between GDM and BMI trajectories, and between GDM and markers of glucose-insulin homeostasis
Methodological detailseffect modification analysis, genetic association
- Effect modification analysis
- Genetic association
Main finding
As reported in the abstract
Average BMI by GLP-1R genotype
- rs10305420 (CT or TT) or rs1042044 (CA or AA) minor allele carriers: GDM exposure associated with higher average BMI; not among major allele homozygotes
- rs6923761: GDM-exposed GG homozygotes had significantly higher average BMI than all other participants
Observational data: associations, not effects.
Further findings
Markers of glucose-insulin homeostasis · adolescence (∼16 years)
- No polymorphisms modified the association between GDM and markers of glucose-insulin homeostasis
Original publication
GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes Mellitus and Offspring BMI Growth: The EPOCH Study. Diabetes Care. Published 30 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →