Gestational diabetes & diabetes in pregnancy
High serum total bilirubin as a potential protective factor for gestational diabetes mellitus: A retrospective cohort study of 92,885 Chinese pregnant women
Authors' conclusion
Our study demonstrated that elevated serum TBIL levels were associated with decreased risk of GDM and supported its potential role in the prevention and early intervention of GDM.
Study context
- Population
- Pregnant women at a tertiary care hospital in Shanghai, China; serum total bilirubin (TBIL) measured at first antenatal visit before 24 weeks of gestation
- Participants
- 92,885 women
- Exposure
- Higher vs lower serum total bilirubin quartiles
- Outcome
- GDM diagnosed by 75-g oral glucose tolerance test (OGTT)
- Follow-up
- 24-28 weeks of gestation
Methodological detailssingle tertiary care hospital
- Single tertiary care hospital
Main finding
As reported in the abstract
GDM risk by TBIL, women with TBIL ≤ 17.1 μmol/l (n = 91,051)
Adjusted odds ratio (95 % CI)
One IQR increase in TBIL (3.4 μmol/l)
0.89(0.87–0.92)
Q2vs Q1
0.92(0.88–0.97)
Q3vs Q1
0.85(0.81–0.90)
Q4vs Q1
0.78(0.74–0.83)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Median TBIL concentration, GDM cases vs women without GDMHigher median TBIL in women with GDM | P < 0.001 |
Gestational diabetes mellitus (GDM) per one IQR increase in TBIL (3.4 μmol/l), women with TBIL ≤ 17.1 μmol/l
- aOR for GDM per one IQR increase in TBIL
- 0.89 [95 % CI 0.87;0.92]
- 91,051 women with TBIL within the physiologically normal range
Median TBIL concentration, GDM cases vs women without GDM
- Women with GDM had a higher median TBIL concentration
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
High serum total bilirubin as a potential protective factor for gestational diabetes mellitus: A retrospective cohort study of 92,885 Chinese pregnant women. Diabetes Metab. Published 8 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →