Gestational diabetes & diabetes in pregnancy
Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study
Authors' conclusion
Greater first trimester BRI, a reflection of central adiposity, is associated with adverse pregnancy outcomes.
Study context
- Population
- Nulliparas with waist circumference, height and weight measured at 6–13 6/7 weeks' gestation
- Participants
- 9,671 participants
- Comparison
- Early pregnancy body roundness index (BRI) quantiles (Q1–Q4), and discordant BRI and BMI quantile assignments
- Primary endpoint
- Adverse pregnancy outcomes
Methodological detailsmulticenter, multivariable logistic regression
- Multicenter
- Multivariable logistic regression
Primary result
As reported in the abstract
Adverse pregnancy outcomes by BRI
- Greater BRI associated with GDM, hypertensive disorders, preterm birth, cesarean delivery and large-for-gestational age infants
- Discordant BRI and BMI assignments affected GDM and cesarean odds
Further findings
GDM, discordant BMI/BRI quantiles
| aOR (CI) | ||
|---|---|---|
| Q2 BMI but Q3-Q4 BRI | 2.28 (1.49–3.47) | |
| Q3 BMI and Q1-Q2 BRI | 0.31 (0.15–0.63) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Cesarean delivery, discordant BMI/BRI quantiles
| aOR (CI) | ||
|---|---|---|
| Q2 BMI but Q3-Q4 BRI | 1.39 (1.15–1.68) | |
| Q3 BMI and Q1-Q2 BRI | 0.75 (0.60–0.94) | |
| Q4 BMI and Q1-Q3 BRI | 0.55 (0.43–0.70) | |
| 0.512Adjusted odds ratio (log scale) |
GDM, discordant BMI/BRI quantiles
- Q4 BMI and Q1-Q3 BRI: similar GDM odds
Original publication
Early Pregnancy Body Roundness Index and Development of Adverse Pregnancy Outcomes: A Secondary Analysis of the nuMoM2b Study. Obesity (Silver Spring). Published 5 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →