Gestational diabetes & diabetes in pregnancy
Remnant Cholesterol Is Associated With Gestational Diabetes Mellitus: A Cohort Study
Authors' conclusion
Elevated RC levels were associated with the increased risk of GDM and independent of traditional risk factors. Pregnant women with high pre-BMI, high TG, and high RC were at greatly increased risk of GDM.
Study context
- Population
- Pregnant women in China; fasting lipids measured around 16 weeks' gestation; Gestational diabetes mellitus (GDM) diagnosed by 75-g OGTT at 24 to 28 weeks' gestation256 (10.1%) developed GDM
- Participants
- 2,528 women
- Exposure
- Quartiles of remnant cholesterol levels
- Outcome
- GDM
- Follow-up
- 24 to 28 weeks' gestation
Methodological detailsTongji Maternal and Child Health Cohort, log-Poisson regression, triglyceride (TG) and remnant cholesterol (RC) mutually adjusted
- Tongji Maternal and Child Health Cohort
- log-Poisson regression
- TG and RC mutually adjusted
Main finding
As reported in the abstract
Adjusted relative risks (RRs) (95% CIs) for GDM across increasing quartiles of RC
1.00 (reference), 1.35 (0.91, 1.99), 1.68 (1.16, 2.45), and 1.73 (1.19, 2.50), respectively
Observational data: associations, not effects.
Further findings
GDM by risk indicators, vs women without 3 risk indicators (TG <2.08 mmol/L, RC <0.40 mmol/L, pre-BMI <24.0 kg/m²)
- Normal pre-BMI but high RC, aRR
- 1.54 (1.08, 2.19) (95% CI)
- Normal pre-BMI but high TG, aRR
- 2.15 (1.33, 3.49) (95% CI)
- All 3 risk indicators, aRR
- 4.80 (3.20, 7.18) (95% CI)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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