Gestational diabetes & diabetes in pregnancy
A prediction model for gestational diabetes mellitus based on steroid hormonal changes in early and mid-down syndrome screening: A multicenter longitudinal study
Authors' conclusion
A GDM prediction model can be constructed using SH measures during early and mid-Down syndrome screening.
Study context
- Population
- Pregnant women with steroid hormone levels measured at early and mid-Down syndrome screeningdiscovery 157, validation 36
- Participants
- 193 women
- Exposure
- Gestational diabetes mellitus (GDM) vs no-GDM
- Outcome
- Predictive performance (AUC) of a logistic regression model for GDM based on steroid hormone changes
Methodological detailsprediction model development and external validation, multicenter
- Prediction model development and external validation
- Multicenter
Main finding
As reported in the abstract
AUC of best stepwise logistic regression model (Δweight, ΔF, Δcortisone, ΔE2, Δprogesterone, ΔDHT)
AUC, discovery model
0.791
AUC, external validation cohort
0.799
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Cortisol (F) at early Down syndrome screeningOnly cortisol elevated in GDM | (95 % CI 4780.95–46083.68) | P < 0.05 |
| Rates of change, GDM vs no-GDM · early to mid-Down syndrome screeningGDM vs no-GDM | Fold change (FC), E2 1.3425 | P = 0.0072 |
| Rates of change, GDM vs no-GDM · early to mid-Down syndrome screeningGDM vs no-GDM | FC, albumin (ALB) 1.5759 | P = 0.0117 |
| Rates of change, GDM vs no-GDM · early to mid-Down syndrome screeningGDM vs no-GDM | FC, dihydrotestosterone (DHT) −2.1234 | P = 0.0165 |
Free testosterone (FT) at mid-Down syndrome screening
- FT significantly elevated (95 % CI 0.10-0.55)
- P < 0.01
Estradiol (E2) at mid-Down syndrome screening
- E2 significantly elevated (95 % CI 203.55-1784.78)
- P < 0.05
Original publication
A prediction model for gestational diabetes mellitus based on steroid hormonal changes in early and mid-down syndrome screening: A multicenter longitudinal study. Diabetes Res Clin Pract. Published 21 September 2024. doi:10.
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