Gestational diabetes & diabetes in pregnancy
Combining HbA1c and insulin resistance to assess the risk of gestational diabetes mellitus: A prospective cohort study
Authors' conclusion
The incidence of GDM increased with increasing HbA1c and HOMA-IR, and the risk of GDM was significantly increased when both HbA1c and HOMA-IR were elevated. This finding may help to identify high-risk women for GDM early in pregnancy and provide timely interventions.
Study context
- Population
- Pregnant women with HbA1c, fasting insulin and fasting glucose (FG) measured at 15–20 weeks of gestation and oral glucose tolerance test (OGTT) at 24–28 weeks, Hangzhou, China
- Participants
- 462 women
- Exposure
- Combinations of HbA1c and homeostasis model assessment insulin resistance (HOMA-IR) for gestational diabetes mellitus (GDM) risk
- Outcome
- GDM occurrence
- Follow-up
- OGTT at 24-28 weeks
Main finding
As reported in the abstract
GDM
Developed GDM
136
29.44%
Observational data: associations, not effects.
Further findings
GDM risk in women <35 years
- No such risk observed in pregnant women <35 years
FG at 24-28 weeks among GDM-positive women
- Significantly higher FG in the high HOMA-IR and HbA1c group
Original publication
Combining HbA1c and insulin resistance to assess the risk of gestational diabetes mellitus: A prospective cohort study. Diabetes Res Clin Pract. Published 17 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →