Gestational diabetes & diabetes in pregnancy
Premeal Whey Protein Lowers Postprandial Blood Glucose in Women With Gestational Diabetes Mellitus: A Randomized, Crossover Clinical Trial
Authors' conclusion
Premeal whey consumption acutely lowers postprandial blood glucose in women with GDM and those with NGT, with 15-30 g lowering the glucose iAUC of women with GDM. These findings emphasize the need for long-term studies to assess the impact of whey premeals in pregnancies affected by GDM.
Study context
- Population
- Pregnant women with and without gestational diabetes mellitus (GDM), 20–36 weeks' gestation; lab and home (CGM) settings12 GDM, 12 normal glucose tolerance (NGT)
- Comparison
- Premeal whey protein vs placebo before oral glucose tolerance test (OGTT)
- Primary endpoint
- Incremental AUC (incremental area under the curve (iAUC)) for glucose
- Follow-up
- 3 hours after OGTT
Methodological detailsplacebo-controlled, single-blinded, crossover
- Placebo-controlled
- Single-blinded
- Crossover
Primary result
As reported in the abstract
Peak glucose after OGTT
Whey vs PlaceboDifference, mmol/L (95% CI)
Women with GDM
−1.0(−1.6 to −0.4)
Women without GDM
−0.7(−1.3 to −0.1)
Further findings
| Outcome | Difference (mmol/L) (95% CI) | |
|---|---|---|
| Incremental glucose peaks at home (CGM), GDM30 g whey; maximum reduction; dose-dependent | −2.0 (−2.5 to −1.5) | |
| −3−2−101Difference, mmol/L (linear scale) |
Insulin, GIP and GLP-1 levels
- Increased rapidly after whey consumption in both groups
Original publication
Premeal Whey Protein Lowers Postprandial Blood Glucose in Women With Gestational Diabetes Mellitus: A Randomized, Crossover Clinical Trial. Diabetes Care. Published 22 April 2025. doi:10.
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