Gestational diabetes & diabetes in pregnancy
Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight
Authors' conclusion
Our findings indicate that altered maternal sugar and energy metabolism, newborn sugar and amino acid metabolism, and newborn C21-steroid hormone biosynthesis were associated with high birth weight. Dysregulated metabolism in pregnant women and newborn may contribute to the pathophysiological mechanisms linking maternal excessive gestational weight gain and multiparity with high birth weight.
Study context
- Population
- Pregnant women and their newborns from the MADRES prospective cohort; maternal serum at third trimester and newborn cord blood
- Participants
- 96 mother–newborn pairs
- Outcome
- Association of maternal and newborn metabolomic features with birth weight Z-score
Methodological detailsuntargeted metabolomics, metabolome-wide association analysis, network analysis
- Untargeted metabolomics
- Metabolome-wide association analysis
- Network analysis
Main finding
As reported in the abstract
Metabolomic signatures of birth weight Z-score
- Maternal glucose and branched-chain amino acid metabolism pathways significantly enriched with high birth weight Z-score
- Newborn fatty acid, glucose metabolism and C21-steroid hormone biosynthesis significantly enriched with high birth weight Z-score
Observational data: associations, not effects.
Further findings
Maternal risk factors and newborn birthweight
- Maternal gestational weight gain and parity positively associated with newborn birthweight
- Dysregulation in these pathways linked gestational weight gain and parity with high birth weight Z-score
Original publication
Dysregulated maternal and newborn fatty acid, sugar and amino acid metabolism associated with high birth weight. Int J Obes (Lond). Published 17 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →