Gestational diabetes & diabetes in pregnancy
Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women
Authors' conclusion
rs10440833, rs10946398, rs4712523, rs4712524 and rs7754840 of CDKAL1 gene are associated with GDM susceptibility in central Chinese population.
Study context
- Population
- Chinese pregnant women at antenatal examination, 24–28 gestational weeks, Maternal and Child Health Hospital of Hubei Province, January 2018–March 2019
- Participants
- 835 vs 870
- Comparison
- Pregnant women with gestational diabetes mellitus (GDM) vs without diabetes
- GDMn = 835
- Controln = 870reference
- Outcome
- Association of CDKAL1 gene polymorphisms (rs10440833, rs10946398, rs4712523, rs4712524, rs7754840, rs7756992, rs9465871) with GDM
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
GDM risk by CDKAL1 genotype
Odds ratio (95% CI)
rs10440833 AAvs rs10440833 TT
1.631(1.192–2.232)
rs10946398 CCvs rs10946398 AA
1.400(1.028–1.905)
rs4712523 GGvs rs4712523 AA
1.409(1.038–1.913)
rs4712524 GGvs rs4712524 AA
1.418(1.043–1.929)
rs7754840 CCvs rs7754840 GG
1.407(1.036–1.911)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Haplotypes, GDM vs controlGDMvs Control | OR (haplotype CGGC) 1.207 (95% CI 1.050–1.387) | ||
| Haplotypes, GDM vs controlGDMvs Control | OR (haplotype AAAG) 0.829 (95% CI 0.721 o 0.952) | P = 0.008 | |
| 0.512Ratio (log scale) |
Linkage disequilibrium among rs10946398, rs4712523, rs4712524 and rs7754840
- Powerful linkage disequilibrium (LD)
- D'>0.900, r2>0.900
Original publication
Association of the CDKAL1 gene polymorphism with gestational diabetes mellitus in Chinese women. BMJ Open Diabetes Res Care. Published 13 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →