Gestational diabetes & diabetes in pregnancy
Gestational Diabetes Mellitus, Postpartum Lipidomic Signatures, and Subsequent Risk of Type 2 Diabetes: A Lipidome-Wide Association Study
Authors' conclusion
GDM was associated with a wide range of lipid metabolic alterations at early postpartum, among which some lipid species were also associated with incident T2D and mediated the progression from GDM to T2D. The improvements attained by including lipid species in the prediction of T2D provides new insights regarding the early detection and prevention of progression to T2D.
Study context
- Population
- Women enrolled 24–72 h after delivery of a singleton baby, Boston Medical Center; mean (SD) age 28.5 (6.6) years
- Participants
- 1,409 women
- Exposure
- Gestational diabetes mellitus (GDM) vs no GDM
- Outcome
- Postpartum lipidomic signature associated with GDM, and the identified lipids' role in progression to T2D
Methodological detailslipidome-wide association study, Lipidome profiled by liquid chromatography-tandem mass spectrometry, GDM and incident T2D from medical records, verified using plasma glucose levels
- Lipidome-wide association study
- Lipidome profiled by liquid chromatography-tandem mass spectrometry
- GDM and incident T2D from medical records, verified using plasma glucose levels
Main finding
As reported in the abstract
Postpartum lipid species associated with GDM
33
Inverse associations (primarily cholesterol esters and phosphatidylcholine plasmalogens)
16
Positive associations (primarily diacyglycerols and triacyglycerols)
17
Observational data: associations, not effects.
Further findings
Incident diabetes · median follow-up 11.8 (IQR 8.2-14.8) years
- Women developing incident diabetes
- 219 (16.4%)
GDM-associated lipids and incident T2D
- Lipid species associated with risk of incident T2D
- 4
- Proportion of progression from GDM to T2D mediated
- ∼12%
Prediction of incident T2D · entire follow-up period
- Identified lipid species modestly improved predictive performance for incident T2D above classical risk factors
Original publication
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