Gestational diabetes & diabetes in pregnancy
Pre-gestational diabetes and the risk of congenital heart defects in the offspring: A French nationwide study
Authors' conclusion
In this study we observed higher incidences of congenital heart defects in infants of women with pre-gestational diabetes compared to women without pre-gestational diabetes, with no difference between women with T1DM or T2DM. These data call for intensifying preconception care and justify systematic cardiac echography in selected fetuses.
Study context
- Population
- All live births in France 2012–2020, French PMSI-MCO databaselive births 2012–2020
- Participants
- 6,038,703 / 23,147 / 14,401
- Exposure
- T1D and T2D vs no pre-gestational diabetes
- No-diabetesn = 6,038,703reference
- T1DMn = 23,147
- T2DMn = 14,401
- Outcome
- Incidence of congenital heart defects in offspring
Methodological detailsPMSI-MCO database, logistic regression
- PMSI-MCO database
- Logistic regression
Main finding
As reported in the abstract
Congenital heart defects
Each group vs no-diabetesOdds ratio (95% CI)P value
T1D
2.07(1.91–2.24)
P < 0.001T2D
2.20(1.99–2.44)
P < 0.001- Incidence across the three groups
- P < 0.001
Observational data: associations, not effects.
Further findings
- Infant congenital disease (any) — No-diabetes
- 6.2%
- Infant congenital disease (any) — Difference across the three groups
- P < 0.001
- Infant congenital disease (any): T1D 8.0%
- Infant congenital disease (any): T2D 8.4%
Other risk factors for congenital heart defects
- Cesarean section, small and large for gestational age, and prematurity were also associated with an increased risk of congenital heart defects
Original publication
Pre-gestational diabetes and the risk of congenital heart defects in the offspring: A French nationwide study. Diabetes Metab. Published 7 April 2023. doi:10.
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