Gestational diabetes & diabetes in pregnancy
Does recurrent gestational diabetes mellitus increase the risk of preterm birth? A population-based cohort study
Authors' conclusion
Maternal GDM increased the risk of preterm birth in nullipara and multipara, whereas recurrent GDM was not associated with a further increase in the risk of prematurity in multiparous mothers. Maternal GDM did not contribute to very preterm birth irrespective of parity. Our findings can be useful for facilitating more targeted preventive strategies for adverse pregnancy outcomes.
Study context
- Population
- Live singleton births to nulliparous and multiparous mothers aged ≥20 years, Qingdao, 2018–2020
- Participants
- 105,528 births
- Exposure
- Previous, current and recurrent gestational diabetes mellitus (GDM) vs no GDM
- Outcome
- Preterm birth (<37 gestational weeks)
Methodological detailslogistic regression, ratio of odds ratios for subgroup differences
- Logistic regression
- Ratio of odds ratios for subgroup differences
Main finding
As reported in the abstract
Estimate (95 % CI)
GDMvs No GDMnullipara
aOR 1.28(1.14–1.45)
GDMvs No GDMmultipara
aOR 1.26(1.14–1.40)
Between Recurrent GDM and Current GDMmultiparous mothers; did not differ significantly
ROR 0.89(0.71–1.12)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Preterm birth, multiparous mothers with pre-pregnancy BMI >30 kg/m²Recurrent GDMvs No GDM | aOR 2.18 (95 % CI 1.25–3.82) | |
| Preterm birth, multiparous mothers with pre-pregnancy BMI >30 kg/m²Recurrent GDMvs Current GDM | ROR 2.20 (95 % CI 1.07–4.52) | |
| 0.20.5125Ratio (log scale) |
Moderate preterm birth (32-36 weeks)
- Risk of GDM for moderate preterm birth similar to that of overall preterm birth
Very preterm birth (<32 weeks)
- GDM not associated with very preterm birth irrespective of parity
- all P values > 0.05
Original publication
Does recurrent gestational diabetes mellitus increase the risk of preterm birth? A population-based cohort study. Diabetes Res Clin Pract. Published 23 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →