Gestational diabetes & diabetes in pregnancy
Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study
Authors' conclusion
This study demonstrates that parity may have a negative effect on early-pregnancy IR and that maternal overweight/obesity appears to further aggravate this relationship.
Study context
- Population
- Healthy pregnant women from the ECLIPSES study recruited at 12 weeks of gestation, Mediterranean population
- Participants
- 264 women
- Exposure
- Parity
- Outcome
- Associations between parity and glucose metabolism parameters (fasting glucose, insulin, HOMA-IR); elevated IR = upper HOMA-IR tertile (≥1.58)
- Follow-up
- First trimester
Main finding
As reported in the abstract
Insulin levels, β [% change] per parity
20.92
95% CI 4.08–37.71
Homeostasis model assessment of insulin resistance (HOMA-IR) index, β [% change] per parity
19.72
95% CI 2.43–40.49
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Elevated IR by parity categoryPrimiparousvs Nulliparous | 1.55 (1.03–2.36) | |
| Elevated IR by parity categoryMultiparousvs Nulliparous | 1.72 (1.05–2.83) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | β [% change] (95% CI) |
|---|---|
| HOMA-IR levels by parity categoryPrimiparous vs Nulliparous | 16.88 (−1.00 to 37.99) |
| HOMA-IR levels by parity categoryMultiparous vs Nulliparous | 32.18 (3.56–68.71) |
Elevated insulin resistance (IR) with multiparity plus overweight/obesity
- Fold increase in RR of elevated IR, increasing proportionally to number of parities
- 3.04
Original publication
Association of Parity With Insulin Resistance Early in Pregnant Women: ECLIPSES Study. J Clin Endocrinol Metab. Published 7 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →