Gestational diabetes & diabetes in pregnancy
Maternal and Infant Outcomes in Glucokinase-maturity-onset Diabetes of the Young (GCK-MODY) Complicated by Pregnancy
Pooled result · Congenital malformationsResult — go to the resultOdds ratio 0.56 95% CI 0.07–4.51Authors' conclusion
The percentage of congenital malformations was 2.4% in GCK-MODY pregnant women's offspring, and newborns with the GCK mutation have lower birth complication than non-GCK mutation carriers.
Study context
- Population
- GCK-MODY mothers and their offspring in observational studies reporting ≥1 pregnancy outcome
- Participants
- 370 mothers8 studies
- Comparison
- GCK-affected vs GCK-unaffected offspring of GCK-MODY mothers
- GCK+n = 238
- GCK-n = 132reference
- Outcome
- Prevalence of congenital anomaly in newborns of GCK-MODY mothers
Methodological detailsNOS risk-of-bias assessment, Search of PubMed, EMBASE and Cochrane to July 16, 2022, 5 studies high quality, 3 medium quality (NOS)
- NOS risk-of-bias assessment
- Search of PubMed, EMBASE and Cochrane to July 16, 2022
- 5 studies high quality, 3 medium quality (NOS)
Pooled result
Congenital malformations
Odds ratio
0.56
95% CI 0.07–4.51
P = 0.59
GCK+vs GCK-
OR 0.56 (95% CI 0.07–4.51); P = 0.59
As reported in the abstract
- Congenital malformations in offspring of GCK-MODY mothers
- 2.4%
Further pooled results
Macrosomia/LGA, neonatal hypoglycemia, combined adverse neonatal outcome
- Risk significantly lower in offspring with the GCK mutation vs non-carriers
Original publication
Maternal and Infant Outcomes in GCK-MODY Complicated by Pregnancy. J Clin Endocrinol Metab. Published 3 April 2023. doi:10.
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