Gestational diabetes & diabetes in pregnancy
Maternal diabetes and fracture risk in offspring: a population-based analysis
Main finding · Any fractureResult — go to the resultHazard ratio 1.07 95% CI 2.7–11.5%Authors' conclusion
In conclusion, maternal diabetes was associated with a modest increase in fracture risk in offspring.
Study context
- Population
- Deliveries in Manitoba, Canada, April 1, 1980–March 31, 2020; deliveries complicated by GDM and T2D identified
- Participants
- 585,176 deliveries
- Exposure
- Offspring of mothers with diabetes vs without diabetes
- Maternal diabetesn = 26,397
- No maternal diabetesn = 558,779reference
- Outcome
- Any incident fracture in offspring
- Follow-up
- Median 15.8 yr
Methodological detailsadministrative health data, Cox proportional hazard regression adjusted for relevant covariates
- Administrative health data
- Cox proportional hazard regression adjusted for relevant covariates
Main finding
Any fracture
Hazard ratio
1.07
95% CI 2.7–11.5%
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
- Types of fractures similar between the 2 groups, predominantly long bone upper extremity fractures
Original publication
Maternal diabetes and fracture risk in offspring: a population-based analysis. J Bone Miner Res. Published 28 March 2024. doi:10.
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