Gestational diabetes & diabetes in pregnancy
Causal relationship between gestational diabetes and preeclampsia: A bidirectional mendelian randomization analysis
Authors' conclusion
Our bidirectional MR analysis offers evidence supporting a causal link between PE and GDM, elucidating their interconnected pathogenesis. Genetic and knowledge-based insights facilitate a deeper comprehension of these complex pregnancy complications.
Study context
- Population
- Public genome-wide association studies (GWAS) data for gestational diabetes mellitus (GDM) and preeclampsia (PE), FinnGen consortium
- Comparison
- GDM ↔ PE, causal effect in both directions
- Outcome
- Causal association between GDM and PE (bidirectional)
Methodological detailsGWAS data from FinnGen consortium, inverse-variance weighted (IVW), MR-Egger and sensitivity analyses, knowledge-based gene identification
- GWAS data from FinnGen consortium
- IVW, MR-Egger and sensitivity analyses
- Knowledge-based gene identification
Main finding
As reported in the abstract
Causal association (IVW mendelian randomization (MR))
Odds ratio (95 % CI)P value
GDMvs PEGDM → PE; no significant association
1.04(0.96–1.14)
P = 0.275PEvs GDMPE → GDM; causal connection
1.14(1.06–1.23)
P < 0.001Further findings
Molecular pathway analysis
- Key genes central to the PE-GDM relationship, including ASAP2
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- Tissue enrichment analysis showed pertinent gene expression in significant tissues
- Lower ASAP2 expression in PE patients' placentas
Original publication
Causal relationship between gestational diabetes and preeclampsia: A bidirectional mendelian randomization analysis. Diabetes Res Clin Pract. Published 26 March 2024. doi:10.
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