Gestational diabetes & diabetes in pregnancy
The causal relationship between 91 inflammatory cytokines and Gestational Diabetes Mmellitus: A bidirectional two-sample Mendelian randomization study
Authors' conclusion
This study has clarified the causal link between inflammatory cytokines and GDM, thereby enhancing our comprehension of the potential mechanisms involved in GDM pathogenesis. These findings offer new insights into the etiology, diagnosis, and therapeutic strategies for GDM.
Study context
- Population
- Publicly accessible genetic data on 91 inflammatory cytokines and Gestational Diabetes Mellitus (GDM)
- Comparison
- 91 inflammatory cytokines and GDM
- Outcome
- Causal association between 91 inflammatory cytokines and GDM
Methodological detailspublicly accessible genetic data, sensitivity analyses
- Publicly accessible genetic data
- Sensitivity analyses
Main finding
As reported in the abstract
Cytokines → GDM risk
- Elevated IL7, associated with increased GDM risk: OR
- 1.104 (95% CI 1.003-1.216, p = 0.042)
- Elevated NRTN, associated with increased GDM risk: OR
- 1.102 (95% CI 1.023-1.187, p = 0.010)
- Decreased GDNF levels associated with increased GDM risk: OR
- 0.911 (95% CI 0.849-0.979, p = 0.010)
- Decreased IL12β levels associated with increased GDM risk: OR
- 0.955 (95% CI 0.916-0.996, p = 0.033)
- Decreased IL20 levels associated with increased GDM risk: OR
- 0.892 (95% CI 0.819-0.971, p = 0.008)
Further findings
GDM → cytokine levels (reverse direction)
- GDM correlates with increased MMP-10: OR
- 1.042 (95% CI 1.002-1.084, p = 0.038)
- GDM correlates with decreased IL-20Rα: OR
- 0.949 (95% CI 0.909-0.992, p = 0.021)
Sensitivity analyses
- No significant heterogeneity or pleiotropy
Original publication
The causal relationship between 91 inflammatory cytokines and Gestational Diabetes Mmellitus: A bidirectional two-sample Mendelian randomization study. Diabetes Res Clin Pract. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →