Gestational diabetes & diabetes in pregnancy

Metabolic factors and perinatal outcomes among pregnant individuals with mild glucose intolerance

Diabetes Res Clin PractPublished Secondary analysis of a randomised controlled trial

Authors' conclusion

Mild glucose intolerance has a similar metabolic profile to treated GDM, and outcome differences are likely related to knowledge of diagnosis and treatment.

Study context

Population
Pregnant individuals from an RCT comparing the IADPSG and Carpenter Coustan criteria
Participants
827 individuals
Comparison
Mild glucose intolerance vs normal glucose tolerance and vs treated GDM
Methodological detailsinverse probability of treatment weighting
  • Inverse probability of treatment weighting

Primary result

As reported in the abstract

Metabolic characteristics and perinatal outcomes
Odds ratio (95% CI)
Mild glucose intolerancevs Normal glucose toleranceSGA
0.13(0.08–0.24)
Mild glucose intolerancevs Normal glucose toleranceneonatal composite morbidity
0.53(0.38–0.74)
Mild glucose intolerancevs Normal glucose tolerancematernal composite morbidity
2.03(1.57–2.62)
Mild glucose intolerancevs Treated GDMLGA
3.42(1.39–8.41)
Mild glucose intolerancevs Treated GDMSGA
0.21(0.05–0.81)
Mild glucose intolerancevs Treated GDMneonatal composite morbidity
0.31(0.17–0.57)

Original publication

Metabolic factors and perinatal outcomes among pregnant individuals with mild glucose intolerance. Diabetes Res Clin Pract. Published 17 August 2024. doi:10.1016/j.diabres.2024.111830

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