Gestational diabetes & diabetes in pregnancy
A comparison of the safety and effectiveness of insulin aspart with other bolus insulins in women with pre‐existing Type 1 diabetes during pregnancy: A post hoc analysis of a prospective cohort study
Authors' conclusion
No significant differences in safety or pregnancy outcomes were demonstrated when comparing treatment with IAsp versus other bolus insulins in women with T1D during pregnancy. The observed improvement in HbA1c with IAsp in late pregnancy should be confirmed in other studies.
Study context
- Population
- Pregnant women with pre-existing T1D in the Diabetes Pregnancy Registry
- Participants
- 1,840 women
- Comparison
- Insulin aspart (IAsp) vs other bolus insulins
- IAspn = 1,434
- Other bolus insulinsn = 406reference
- Primary endpoint
- Composite: proportion of pregnancies resulting in major congenital malformations or perinatal or neonatal death
Methodological detailsreal-world setting, propensity score-adjusted analyses
- Real-world setting
- Propensity score-adjusted analyses
Primary result
As reported in the abstract
Composite of major congenital malformations or perinatal or neonatal death (pregnancy outcomes)
- No significant differences in any pregnancy outcome between IAsp and other bolus insulins, in crude or propensity score-adjusted analyses
Secondary outcomes
| Outcome | Adjusted difference (% point) (95% CI) | P value | |
|---|---|---|---|
| Maternal HbA1c · end of third trimesterIAspvs Other bolus insulins | −0.16 (−0.28 to −0.05) | P = 0.0046 | |
| −0.4−0.200.2Difference, % point (linear scale) |
| Outcome | Adjusted difference (mmol/mol) (95% CI) | P value | |
|---|---|---|---|
| Maternal HbA1c · end of third trimesterIAspvs Other bolus insulins | −1.8 (−3.1 to −0.6) | P = 0.0046 | |
| −4−202Difference, mmol/mol (linear scale) |
Original publication
A comparison of the safety and effectiveness of insulin aspart with other bolus insulins in women with pre‐existing Type 1 diabetes during pregnancy: A post hoc analysis of a prospective cohort study. Diabet Med. Published 8 August 2024. doi:10.
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