Gestational diabetes & diabetes in pregnancy
N-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus
Authors' conclusion
NT-proBNP levels are lower in South Asian than in Nordic women after GDM. Lower NT-proBNP levels correlate with impaired insulin sensitivity. Lower NT-proBNP levels in South Asian women could, therefore, be attributed to impaired insulin sensitivity rather than total body fat.
Study context
- Population
- Women in Norway 1–3 years after gestational diabetes mellitus (GDM); mean (SD) age 35.3 (4.5) years, BMI 29.1 (6.0) kg/m², 164 (61%) with prediabetes/diabetes
- Participants
- 162 vs 107
- Exposure
- South Asian vs Nordic women after GDM
- South Asiann = 162
- Nordicn = 107reference
- Outcome
- Ethnic differences in circulating NT-proBNP levels
- Follow-up
- 1-3 years after GDM
Methodological detailsmediation analysis
- Mediation analysis
Main finding
As reported in the abstract
NT-proBNP
P < 0.001
Observational data: associations, not effects.
Further findings
Association of higher NT-proBNP with greater insulin sensitivity
- South Asian women: higher NT-proBNP associated with greater insulin sensitivity
- P = 0.005
- Nordic women: higher NT-proBNP associated with greater insulin sensitivity
- P < 0.001
Inflammatory and metabolic markers, South Asian vs Nordic
- High-sensitivity C-reactive protein (hsCRP), median (IQR), South Asian vs Nordic
- 2.2 (1.1-4.4) vs. 1.2 (0.3-4.2) mg/L
- IL-6, South Asian vs Nordic
- 2.3 (1.5-3.2) vs. 1.5 (1.5-2.5) pg/mL
- Leptin, South Asian vs Nordic
- 1647 (1176-2480) vs. 1223 (876-2313) pmol/L
- Adiponectin, lower in South Asian vs Nordic
- 7.2 (5.3-9.3) vs. 10.0 (7.2-13.5) mg/L
- Matsuda Insulin Sensitivity Index (ISI), lower in South Asian vs Nordic
- 2.4 (1.7-3.7) vs. 4.2 (2.9-6.1)
- P for all comparisons
- pall<0.01
NT-proBNP and insulin sensitivity after adjustment
- Higher NT-proBNP per SD Matsuda ISI
- 22%, p = 0.015
- Adjusted for ethnic differences in markers
Mediation of ethnic difference in NT-proBNP
- Mediated by insulin sensitivity
- 53%
- Mediated by adiponectin
- 41%
Original publication
N-terminal pro-B-type natriuretic peptide levels vary by ethnicity and are associated with insulin sensitivity after gestational diabetes mellitus. Cardiovasc Diabetol. Published 3 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →