Gestational diabetes & diabetes in pregnancy

Ethnic Differences in Characteristics of Women Diagnosed With Early Gestational Diabetes: Findings From the TOBOGM Study

J Clin Endocrinol MetabPublished Secondary analysis of the TOBOGM randomised controlled trial

Authors' conclusion

In women with risk factors, eGDM was most prevalent in SA and ESEA women, particularly identified by the post-glucose load samples. These findings suggest an early oral glucose tolerance test should particularly be performed in women from these ethnic groups.

Study context

Population
Pregnant women with GDM risk factors enrolled at <20 weeks' gestation; GDM by WHO-2013 criteria; ethnicity by self-identification
Participants
1,567 / 971 / 498 / 242 / 174
Comparison
Ethnic groups: Europid vs South Asian, East and South-East Asian, Middle Eastern, Māori and Pasifika
  • Europidn = 1,567reference
  • SAn = 971
  • ESEAn = 498
  • MEn = 242
  • MPn = 174
Methodological detailsinternational, multicenter
  • International
  • Multicenter

Primary result

As reported in the abstract

eGDM crude prevalence
eGDM
Each group vs europidAdjusted odds ratio (95% CI)
SA
2.43(1.9–3.11)
ESEA
2.28(1.68–3.08)
Crude eGDM prevalence differed across ethnic groups; highest in MP
P < 0.001

Further findings

OutcomeValuesaOR (95% CI)
Late GDM prevalenceSAvs EuropidSA had highest late GDM prevalenceSA 20.4%2.16 (1.61–2.9)

Glucose pattern at eGDM diagnosis

ESEA mainly diagnosed through post-glucose load values; all other groups mainly on fasting glucose

eGDM composite primary outcome, neonatal and pregnancy-related hypertension outcomes

No differences between ethnic groups

Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.

Original publication

Ethnic Differences in Characteristics of Women Diagnosed With Early Gestational Diabetes: Findings From the TOBOGM Study. J Clin Endocrinol Metab. Published 6 December 2024. doi:10.1210/clinem/dgae838

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