Gestational diabetes & diabetes in pregnancy
Sensor‐derived glycaemic metrics in pregnant women with type 1 diabetes randomised to faster acting insulin aspart or insulin aspart—A secondary analysis of the CopenFast trial
Primary result · TIRp (3.5-7.8 mmol/L)Result — go to the resultEstimated treatment difference 5.1 % 95% CI 0.3–9.7Authors' conclusion
Women using faster aspart achieved more TIRp and experienced less severe hypoglycaemia compared to women using IAsp. Infant birthweight was lower and thereby more appropriate in the faster aspart group; however, this attenuated when adjusting for parity.
Study context
- Population
- Pregnant women with T1D using intermittently scanned continuous glucose monitoring (isCGM) during pregnancy91% of 124 isCGM users
- Participants
- 113 women
- Comparison
- Faster aspart vs insulin aspart (IAsp)
Methodological detailspre-planned secondary analysis
- Pre-planned secondary analysis
Primary result
TIRp (3.5-7.8 mmol/L) · 22 to 33 weeks
Estimated treatment difference
5.1 %
95% CI 0.3–9.7
P = 0.04
Faster aspartvs IAsp
estimated treatment difference 5.1 % (95% CI 0.3–9.7); P = 0.04
As reported in the abstract
Further findings
| Outcome | Estimated treatment difference (CI) | P value | |
|---|---|---|---|
| Infant birthweight SD score | −0.5 (−0.9 to −0.03) | P = 0.04 | |
| −1−0.500.5Difference (linear scale) |
- Infant birthweight SD score — Attenuated when adjusting for parity
- p = 0.10
Time below range in pregnancy (TBRp) (<3.5 mmol/L) · throughout pregnancy
- TBRp remained stable around 4% in both groups
Safety
≥1 severe hypoglycaemic event
- OR (abstract does not state which group each count belongs to; OR lies outside its printed interval)
- 0.93 [−0.2; −0.01]
- P
- P = 0.04
Original publication
Sensor‐derived glycaemic metrics in pregnant women with type 1 diabetes randomised to faster acting insulin aspart or insulin aspart—A secondary analysis of the CopenFast trial. Diabet Med. Published 4 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →