Gestational diabetes & diabetes in pregnancy
Heterogeneity of Gestational Diabetes and Risk for Adverse Pregnancy Outcome: A Cohort Study
Authors' conclusion
GDM exhibits distinct insulin physiology profiles. Pregnancy outcome varies between each phenotype. These findings provide evidence on risk stratification and diverse strategies for the treatment of GDM.
Study context
- Population
- Pregnant women who underwent a 75-g OGTT, followed until delivery
- Participants
- 2,050 women
- Exposure
- GDM phenotypes: gestational-IFG vs gestational-IGT vs NGT
- NGTn = 936reference
- gestational-IFGn = 378
- gestational-IGTn = 736
- Outcome
- Insulin physiology (gestational-IFG vs gestational-IGT)
- Follow-up
- Mid-pregnancy
Main finding
As reported in the abstract
- gestational-IFG vs gestational-IGT: P < 0.01
- gestational-IFG vs gestational-IGT: P < 0.01
- gestational-IGT vs gestational-IFG: P < 0.05
Observational data: associations, not effects.
Further findings
| Outcome | RR (95% CI) | |
|---|---|---|
| Excessive gestational weight gaingestational-IFGvs gestational-IGT | 1.62 (1.18–2.23) | |
| Large-for-gestational-age infantsgestational-IFGvs gestational-IGT | 1.45 (1.03–2.03) | |
| Neonatal brain injurygestational-IGTvs NGTIncreased risk in gestational-IGT | 2.03 (1.04–4.09) | |
| Preterm birthgestational-IGTvs gestational-IFG | 1.80 (1.02–3.36) | |
| 0.20.5125Relative risk (log scale) |
| Outcome | P value |
|---|---|
| Neonatal brain injurygestational-IFG vs NGT · risk not increased in gestational-IFG | P = 0.439 |
Original publication
Heterogeneity of Gestational Diabetes and Risk for Adverse Pregnancy Outcome: A Cohort Study. J Clin Endocrinol Metab. Published 24 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →