Gestational diabetes & diabetes in pregnancy
Body mass index trajectories and time in target range after delivery and long‐term type 2 diabetes risk in women with a history of gestational diabetes mellitus
Authors' conclusion
Postpartum BMI trajectories of high-stable and inverse U-shape class as well as lower TTR were associated with an increased risk of type 2 diabetes among women with a history of GDM. Reducing BMI to a normal range in the early postpartum period and maintaining stable over time could attenuate the development of long-term type 2 diabetes.
Study context
- Population
- Women with a history of Gestational Diabetes Mellitus (GDM) in the Tianjin Gestational Diabetes Mellitus Prevention Program (TGDMPP)
- Participants
- 1,057 women
- Exposure
- Postpartum body mass index (BMI) trajectory classes and BMI time in target range
- Outcome
- T2D, diagnosed by OGTT or physician diagnosis
- Follow-up
- Median 8.47 years
Methodological detailslatent class modelling, multivariable Cox modelling
- Latent class modelling
- Multivariable Cox modelling
Main finding
As reported in the abstract
T2D risk by postpartum BMI trajectory
Each group vs low-stableAdjusted hazard ratio (95% CI)P value
Median-stable
2.02(0.99–4.10)
P = 0.012for trendHigh-stable
3.01(1.17–7.73)
P = 0.012for trendU-shape
2.15(0.63–7.38)
P = 0.012for trendInverse U-shape
7.15(2.08–24.5)
P = 0.012for trendObservational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | P value | |
|---|---|---|---|
| T2D risk by postpartum BMI TTR (BMI 18.5–<24.0 kg/m²)TTR >43.4%-<100%vs TTR 100% | 1.84 (0.72–4.73) | P for trend = 0.039 | |
| T2D risk by postpartum BMI TTR (BMI 18.5–<24.0 kg/m²)TTR >0%-≤43.4%vs TTR 100% | 2.75 (1.23–6.15) | P for trend = 0.039 | |
| T2D risk by postpartum BMI TTR (BMI 18.5–<24.0 kg/m²)TTR 0%vs TTR 100% | 2.31 (1.05–5.08) | P for trend = 0.039 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
- T2D risk by postpartum BMI time in target range (TTR) (BMI 18.5–<24.0 kg/m²): TTR 100% reference (HR 1.00)
Original publication
Body mass index trajectories and time in target range after delivery and long‐term type 2 diabetes risk in women with a history of gestational diabetes mellitus. Diabetes Obes Metab. Published 21 October 2024. doi:10.
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