Gestational diabetes & diabetes in pregnancy
Glycemic status during pregnancy according to fasting and post-load glucose values: The association with adverse pregnancy outcomes. An observational study
Authors' conclusion
Despite glucose-lowering care and adjustment for confounders, compared with no HIP, fasting HIP was associated with a higher rate of LGA infant, whereas post-load HIP was associated with higher preterm delivery and neonatal intensive care unit admission rates.
Study context
- Population
- Women screened for treated hyperglycemia in pregnancy (HIP) after 22 weeks of gestation
- Participants
- 8,339 women
- Exposure
- HIP status by oral glucose tolerance test (OGTT) fasting and/or post-load glucose vs no HIP
- No HIPn = 6,832reference
- Isolated fasting HIPn = 465
- Isolated post-load HIPn = 646
- Fasting and post-load HIPn = 396
- Outcome
- Large-for-gestational-age (LGA) infant
Methodological detailsmultiethnic, observational
- Multiethnic
- Observational
Main finding
As reported in the abstract
LGA infant
Each group vs no HIPAdjusted odds ratio (95% CI)
Isolated fasting HIP
1.47(1.11–1.96)
Fasting and post-load HIP
1.65(1.23–2.21)
Isolated post-load HIP
1.13(0.86–1.48)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| Preterm deliveryIsolated post-load HIPvs No HIPAdjusted | 1.44 (1.03–2.03) | |
| Preterm deliveryFasting and post-load HIPvs No HIPAdjusted | 1.81 (1.23–2.68) | |
| Preterm deliveryIsolated fasting HIPvs No HIPAdjusted | 1.34 (0.90–2.00) | |
| Neonatal ICU admissionIsolated post-load HIPvs No HIPAdjusted | 1.28 (1.04–1.57) | |
| Neonatal ICU admissionFasting and post-load HIPvs No HIPAdjusted | 1.42 (1.10–1.81) | |
| Neonatal ICU admissionIsolated fasting HIPvs No HIPAdjusted | 1.20 (0.94–1.52) | |
| 0.20.5125Adjusted odds ratio (log scale) |
Original publication
Glycemic status during pregnancy according to fasting and post-load glucose values: The association with adverse pregnancy outcomes. An observational study. Diabetes Metab. Published 28 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →