Gestational diabetes & diabetes in pregnancy
Associations between maternal gestational diabetes metformin or insulin treatment and offspring growth trajectories from birth to 60 months of age: Findings from the Born in Bradford (BiB) study
Authors' conclusion
GDM metformin treatment was not associated with differences in offspring growth trajectories compared to insulin treatment. Both metformin and insulin-exposed offspring had comparable BMI z-score to No-GDM by 60 months.
Study context
- Population
- Offspring in the Born in Bradford birth cohort
- Participants
- 76 / 420 / 9,171
- Exposure
- Offspring of gestational diabetes mellitus (GDM) treated with metformin vs insulin, and each vs no GDM
- OGDM-Metforminn = 76
- OGDM-Insulinn = 420
- No-GDMn = 9,171reference
- Outcome
- Weight, height and BMI z-score trajectories
- Follow-up
- 0 to 60 months
Methodological detailscovariate-adjusted multilevel linear spline models
- Covariate-adjusted multilevel linear spline models
Main finding
As reported in the abstract
Growth trajectories (weight, height, BMI z-scores)
OGDM-Metformin vs No-GDM: faster change in height z-score from 17 to 60 months
0.13
95% CI 0.026, 0.24
OGDM-Insulin vs No-GDM: faster change in weight z-score from 1.6 to 6 months
0.32
0.021, 0.62
OGDM-Insulin vs No-GDM: faster change in height z-score from 1.6 to 6 months
0.50
0.087, 0.91
Observational data: associations, not effects.
Original publication
Associations between maternal gestational diabetes metformin or insulin treatment and offspring growth trajectories from birth to 60 months of age: Findings from the Born in Bradford (BiB) study. Diabet Med. Published 26 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →