Gestational diabetes & diabetes in pregnancy
Gestational diabetes mellitus and size at birth modify early adiposity accretion. Evidence from the OBESO cohort
Authors' conclusion
GDM appears to program early higher adiposity accretion, independently of excessive fetal growth. SGA was associated with higher FM accretion in early infancy.
Study context
- Population
- Healthy pregnant women and their term babies from the OBESO cohort; Pregestational body-mass-index (preBMI) 27.4 ± 5.2 kg/m²90 to 6 M
- Participants
- 122 women
- Exposure
- Maternal obesity, GDM and birth size (SGA/LGA) as predictors of infant fat-mass accretion
- Outcome
- Infant fat-mass accretion (ΔkgFM, air-displacement plethysmography)
- Follow-up
- 1 M-3 M and 1 M-6 M
Methodological detailsadjusted multiple linear regression
- Adjusted multiple linear regression
Main finding
As reported in the abstract
FM accretion
1 M-3 M: SGA predictor of higher fat-mass (FM) accretion, B
0.28 (0.14-0.43) (95% CI)
1 M-6 M: SGA, higher FM accretion, B
0.43 (0.19-0.67) (95% CI)
1 M-6 M: GDM, higher FM accretion, B
0.48 (0.06-0.89) (95% CI)
Observational data: associations, not effects.
Further findings
Cohort characteristics
- GDM
- 9% (n = 11)
- Received metformin/insulin
- 12.3% (n = 15)
- LGA newborns
- 1
- SGA newborns
- 20.7% (n = 25)
Original publication
Gestational diabetes mellitus and size at birth modify early adiposity accretion. Evidence from the OBESO cohort. Diabetes Res Clin Pract. Published 25 August 2023. doi:10.
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