Gestational diabetes & diabetes in pregnancy
Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy
Authors' conclusion
Declining beta cell function is the dominant determinant of incident prediabetes/diabetes in young women following pregnancy.
Study context
- Population
- Women with normal glucose tolerance on OGTT at 3 months postpartum, spanning normoglycaemia to gestational diabetes in pregnancy
- Participants
- 302 women
- Exposure
- Progressors vs non-progressors to prediabetes/diabetes
- Progressorsn = 89
- Outcome
- Determinants of incident prediabetes/diabetes, ranked by change in concordance index (CCI) of Cox proportional hazard models
- Follow-up
- 5 years postpartum
Methodological detailsserial OGTT at 3 months, 1 year, 3 years and 5 years postpartum
- Serial OGTT at 3 months, 1 year, 3 years and 5 years postpartum
Main finding
As reported in the abstract
Change in CCI for progression to prediabetes/diabetes (time-varying determinants) · over 5 years
Time-varying ISSI-2
25.2%
Time-varying IGI/HOMA-IR
13.0%
Time-varying Matsuda index
2.9%
Time-varying HOMA-IR
0.5%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Characteristics at 3 months postpartum, progressors vs non-progressorsProgressors vs Non-progressors · higher fasting glucose in progressors | P = 0.03 |
| Characteristics at 3 months postpartum, progressors vs non-progressorsProgressors vs Non-progressors · higher 2 h glucose in progressors | P < 0.0001 |
| Characteristics at 3 months postpartum, progressors vs non-progressorsProgressors vs Non-progressors · higher BMI in progressors | P = 0.001 |
| Characteristics at 3 months postpartum, progressors vs non-progressorsProgressors vs Non-progressors | P ≤ 0.02 |
| Characteristics at 3 months postpartum, progressors vs non-progressorsProgressors vs Non-progressors | P ≤ 0.006 |
- Characteristics at 3 months postpartum, progressors vs non-progressors: greater insulin resistance (Matsuda index and HOMA-IR) in progressors
- Characteristics at 3 months postpartum, progressors vs non-progressors: poorer beta cell function (ISSI-2 and IGI/HOMA-IR) in progressors
Beta cell function trajectory · 1 year to 5 years
- Progressors, unlike peers, had deteriorating beta cell function (both p<0.0001)
Original publication
Deteriorating beta cell function is the dominant determinant of progression from normal glucose tolerance to prediabetes/diabetes in young women following pregnancy. Diabetologia. Published 24 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →