Gestational diabetes & diabetes in pregnancy
Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood
Authors' conclusion
Ascending early growth was associated with lower maternal total cholesterol in HDL in 2nd and 3rd trimester, and higher VLDL size and more adverse TG/PG ratio in cord blood.
Study context
- Population
- Mother-child dyads; women at high risk for gestational diabetes mellitus (GDM) (BMI ≥ 30 kg/m² and/or prior GDM) recruited before or in early pregnancydyads with growth profile data
- Participants
- 572 dyads
- Comparison
- Offspring early growth profiles (ascending vs intermediate vs descending) by maternal and cord blood metabolite profile
- Ascendingn = 80
- Intermediaten = 346
- Descendingn = 146
Methodological detailscohort, metabolomics by targeted nuclear magnetic resonance (NMR), latent class mixed models, Metabolomic data: 232 mothers 1st trimester, 271 2nd, 277 3rd, 345 cord blood; 220 metabolites per trimester, 70 cord blood
- Cohort
- Metabolomics by targeted NMR
- Latent class mixed models
- Metabolomic data: 232 mothers 1st trimester, 271 2nd, 277 3rd, 345 cord blood; 220 metabolites per trimester, 70 cord blood
Primary result
As reported in the abstract
Maternal lipoprotein profile by offspring growth profile · each trimester
- Mothers of ascending group: higher VLDL and LDL particles, lower HDL particles in each trimester
- p < 0.05
- Adjusted association of ascending profile with 2nd trimester total cholesterol in HDL2, 3rd trimester total cholesterol in HDL2 and HDL, and cord blood VLDL size and TG/PG ratio
- p ≤ 0.002
Original publication
Early ascending growth is associated with maternal lipoprotein profile during mid and late pregnancy and in cord blood. Int J Obes (Lond). Published 17 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →