Gestational diabetes & diabetes in pregnancy
Association between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study
Authors' conclusion
Children exposed to GDM had greater suprailiac skinfold thickness than unexposed children, despite having lower mean weight, BMI and mid-upper arm circumference, and both GDM and T2D were associated with smaller mean head circumference. Future research should assess whether childhood anthropometric differences influence lifetime cardiometabolic and neurodevelopmental risk.
Study context
- Population
- Children of women with gestational diabetes mellitus (GDM), T2D (hyperglycemia in pregnancy register) or normoglycemia (community), PANDORA cohort; Wave 1 children aged 1.5–5 years (median follow-up age 2.5 years)Wave 1 children
- Participants
- 423 children
- Exposure
- Maternal GDM or T2D vs normoglycemia in pregnancy
- Outcome
- Offspring anthropometry (weight, height, BMI, skinfold thicknesses, waist, arm and head circumferences)
- Follow-up
- Aged 1.5-5 years (median 2.5 years)
Main finding
As reported in the abstract
Offspring anthropometry, adjusted incl. maternal BMI
Each group vs normoglycemiaMean difference, weight, kg (95% CI)
GDM
−0.54(−0.99 to −0.11)
Each group vs normoglycemiaMean difference, BMI, kg/m2 (95% CI)
GDM
−0.55(−0.91 to −0.20)
Each group vs normoglycemiaEstimate (95% CI)
GDM
mean difference, head circumference −0.52 cm(−0.88 to −0.16)
GDM
mean difference, mid-upper arm circumference −0.32 cm(−0.63 to −0.01)
T2D
mean difference, head circumference −0.82 cm(−1.33 to −0.31)
Each group vs normoglycemiaMean difference, suprailiac skinfold, mm (95% CI)
GDM
0.78(0.13–1.43)
- Maternal T2D no longer associated with greater child mean skinfolds after adjustment for maternal body mass index (BMI)
- P = 0.14
- Maternal T2D no longer associated with greater child waist circumference after adjustment for maternal BMI
- P = 0.18
Observational data: associations, not effects.
Further findings
Maternal antenatal BMI and offspring anthropometry
- Greater maternal antenatal BMI associated with increased offspring anthropometric measures, independent of maternal glycemic status
Original publication
Association between maternal hyperglycemia in pregnancy and offspring anthropometry in early childhood: the pandora wave 1 study. Int J Obes (Lond). Published 22 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →