Gestational diabetes & diabetes in pregnancy
Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes
Authors' conclusion
Altered lipid metabolism is a key pathophysiological feature of type 1 diabetes pregnancy. New strategies for optimising maternal diet and insulin dosing from the first trimester are needed to improve pregnancy outcomes in type 1 diabetes.
Study context
- Population
- Pregnant women with T1D in CONCEPTT; maternal non-fasting serum at 12, 24 and 34 gestational weeks and cord bloodcord blood from 93 infants
- Participants
- 174 women
Methodological detailsuntargeted metabolomics (ultrahigh performance LC-MS), adjusted logistic/linear regression, modified Bonferroni limit of significance
- Untargeted metabolomics (ultrahigh performance LC-MS)
- Adjusted logistic/linear regression
- Modified Bonferroni limit of significance
Primary result
As reported in the abstract
- Maternal CGM time-above-range (but not BMI or excessive gestational weight gain) associated with increased maternal triacylglycerols and increased cord blood carnitines
- LGA, adiposity, neonatal hypoglycaemia and offspring hyperinsulinism showed distinct metabolite profiles
- LGA associated with increased carnitines, steroid hormones and lipid metabolites, predominantly in third trimester
- Neonatal hypoglycaemia and offspring hyperinsulinism associated with metabolite changes from first trimester, featuring triacylglycerols or dietary phenols
- Pre-eclampsia associated with increased phosphatidylethanolamines at 24 weeks
Original publication
Metabolomic insights into maternal and neonatal complications in pregnancies affected by type 1 diabetes. Diabetologia. Published 24 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →