Gestational diabetes & diabetes in pregnancy
Early‐Onset Versus Late‐Onset Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Maternal, Perinatal and Neonatal Outcomes
Authors' conclusion
eGDM versus LGDM is associated with higher risks of adverse outcomes, particularly insulin initiation.
Study context
- Population
- Pregnancies with gestational diabetes mellitus (GDM), by timing of diagnosis
- Participants
- 105,123 pregnancies35 studies
- Comparison
- Early-onset GDM vs late-onset GDM
- Outcome
- Insulin initiation, caesarean delivery, preterm birth, large-for-gestational-age (LGA) infants and neonatal intensive care unit (NICU) admission
Methodological detailsrandom-effects models, meta-regression, subgroup analyses, sensitivity analyses, GRADE
- Random-effects models
- Meta-regression
- Subgroup analyses
- Sensitivity analyses
- GRADE
Pooled result
As reported in the abstract
eGDM vs LGDMOdds ratio (95% CI)
Insulin initiation
2.26(1.75–2.91)
Caesarean delivery
1.16(1.01–1.33)
Preterm birth
1.32(1.05–1.64)
LGA
1.29(1.06–1.58)
NICU admission
1.24(1.03–1.50)
- Heterogeneity I2
- 57.3%-86.5%
Original publication
Early‐Onset Versus Late‐Onset Gestational Diabetes Mellitus: A Systematic Review and Meta‐Analysis of Maternal, Perinatal and Neonatal Outcomes. Diabetes Obes Metab. Published 9 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →