Gestational diabetes & diabetes in pregnancy
Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes
Authors' conclusion
EGDM in women without obesity is associated with a high risk for postpartum glucose intolerance. This could be related to impaired insulin secretion rather than insulin resistance. These findings highlight the need for close monitoring and tailored interventions for patients with EGDM. More research is required to improve diagnostic and management strategies, considering ethnic variations in insulin secretion and glucose tolerance.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) diagnosed by 75 g OGTT, Japan
- Participants
- 107 vs 109
- Exposure
- Early-onset GDM vs late-onset GDM
- EGDMn = 107
- Late GDM (LGDM)n = 109reference
- Outcome
- Postpartum glucose intolerance
- Follow-up
- 4-16 weeks post partum
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Postpartum glucose intolerance was more prevalent with EGDM, particularly in those without obesity
Observational data: associations, not effects.
Further findings
Insulin secretion and resistance
- Significantly lower initial insulin secretion capacity in EGDM without obesity
- Insulin resistance was comparable between the groups
- Subgroup: women without obesity
Pregnancy outcomes
- Gestational weight gain significantly lower with EGDM than LGDM
- Neonatal birth weight, small and large for gestational age comparable between groups
Original publication
Perinatal and postpartum insulin secretion capacity in women with early-onset and late-onset gestational diabetes. BMJ Open Diabetes Res Care. Published 5 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →