Gestational diabetes & diabetes in pregnancy

Association between gestational diabetes mellitus and postpartum depression: an updated systematic review and meta-analysis

Diabetes Res Clin PractPublished Systematic review and meta-analysis

Pooled result · PPDResult — go to the resultRelative risk 1.42 95% CI 1.17–1.72

Authors' conclusion

Finally, the results of this systematic review and meta-analysis provide strong evidence that GDM is an important risk factor for PPD.

Study context

Population
Mothers in studies of gestational diabetes mellitus (GDM) and postpartum depression (PPD)
Participants
2,442,001 mothers29 studies
Comparison
Mothers with GDM vs mothers without GDM
Outcome
Postpartum depression (PPD)
Methodological detailsPRISMA reporting, MOOSE guidelines, updated
  • PRISMA reporting
  • MOOSE guidelines
  • Updated

Pooled result

PPD

Relative risk

1.42

95% CI 1.17–1.72

P < 0.001

GDMvs No GDM
RR 1.42 (95% CI 1.17–1.72); P < 0.001

As reported in the abstract

Further pooled results

Subgroup analyses for sources of heterogeneity

Study design: not significant
P = 0.085
Study type: not significant
P = 0.357
Duration of PPD measurement: not significant
P = 0.329
Continent: not significant
P = 0.163
PPD measurement tool: significant
P < 0.001

Original publication

Association between gestational diabetes mellitus and postpartum depression: an updated systematic review and meta-analysis. Diabetes Res Clin Pract. Published 3 October 2025. doi:10.1016/j.diabres.2025.112922

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