Gestational diabetes & diabetes in pregnancy
Association between gestational diabetes mellitus and postpartum depression: an updated systematic review and meta-analysis
Pooled result · PPDResult — go to the resultRelative risk 1.42 95% CI 1.17–1.72Authors' conclusion
Finally, the results of this systematic review and meta-analysis provide strong evidence that GDM is an important risk factor for PPD.
Study context
- Population
- Mothers in studies of gestational diabetes mellitus (GDM) and postpartum depression (PPD)
- Participants
- 2,442,001 mothers29 studies
- Comparison
- Mothers with GDM vs mothers without GDM
- Outcome
- Postpartum depression (PPD)
Methodological detailsPRISMA reporting, MOOSE guidelines, updated
- PRISMA reporting
- MOOSE guidelines
- Updated
Pooled result
PPD
Relative risk
1.42
95% CI 1.17–1.72
P < 0.001
GDMvs No GDM
RR 1.42 (95% CI 1.17–1.72); P < 0.001
As reported in the abstract
Further pooled results
Subgroup analyses for sources of heterogeneity
- Study design: not significant
- P = 0.085
- Study type: not significant
- P = 0.357
- Duration of PPD measurement: not significant
- P = 0.329
- Continent: not significant
- P = 0.163
- PPD measurement tool: significant
- P < 0.001
Original publication
Association between gestational diabetes mellitus and postpartum depression: an updated systematic review and meta-analysis. Diabetes Res Clin Pract. Published 3 October 2025. doi:10. 1016/ j. diabres. 2025. 112922
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