Gestational diabetes & diabetes in pregnancy
Treatment of women with mild gestational diabetes mellitus decreases the risk of adverse perinatal outcomes
Authors' conclusion
The diagnosis of GDM using the two-step OGTT fails to identify subgroups of women with mild hyperglycemia that would benefit from treatment to lower the risk for adverse maternal and neonatal outcomes. Treatment of women with mild hyperglycemia decreased the risk of LGA and birthweight >4000 g by 3-fold.
Study context
- Population
- Women with singleton pregnancies >32-week gestation and intermediate hyperglycemia (FPG 5.1–5.2 mmol/L, 1 h PG 10.0–10.5 mmol/L, or 2 h PG 8.5–8.9 mmol/L at 75 g oral glucose tolerance test (OGTT)), two tertiary care centers11,553 charts reviewed
- Participants
- 630 women
- Exposure
- Untreated vs treated intermediate hyperglycemia
- Untreatedn = 334
- Treatedn = 296reference
- Outcome
- Adverse maternal and neonatal outcomes
Methodological detailstwo tertiary care centres, chart review
- Two tertiary care centres
- Chart review
Main finding
As reported in the abstract
Adjusted odds ratio
6.02
P = 0.002
gestational hypertension
Adjusted odds ratio
3.73
P < 0.001
Large for gestational age (LGA)
Adjusted odds ratio
3.35
P = 0.001
birthweight > 4000 g
- NNT to prevent one LGA birth
- 11
- NNT to prevent 1 birthweight > 4000 g
- 13
Observational data: associations, not effects.
Original publication
Treatment of women with mild gestational diabetes mellitus decreases the risk of adverse perinatal outcomes. Diabetes Metab. Published 17 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →