Gestational diabetes & diabetes in pregnancy
The Glucose Challenge Test in Pregnancy Identifies Future Risk of Diabetes
Authors' conclusion
The GCT offers predictive capacity for future diabetes in pregnant women. In women with GDM, this insight could identify those at highest risk of diabetes, toward whom postpartum screening efforts should be most strongly directed.
Study context
- Population
- Women in Ontario, Canada, with a glucose challenge test (GCT) in pregnancy and delivery between January 2007 and December 2017, followed by HbA1c and fasting glucose within 2 years postpartum19,034 with GDM
- Participants
- 141,858 women
- Exposure
- Antenatal GCT 1-h glucose vs postpartum HbA1c for predicting future diabetes
- Outcome
- Development of diabetes
- Follow-up
- Median 3.5 years
Methodological detailsadministrative databases
- Administrative databases
Main finding
As reported in the abstract
Diabetes per 1-h post-challenge glucose on GCT (linear exposure effect)
HR (95% CI 1.38-1.40) for developing diabetes
1.39
GCT threshold predicting same 5-year diabetes risk as postpartum HbA1c 5.7% (prediabetes)
8.0 mmol/L
5-year diabetes risk at that threshold
6.0%
95% CI 5.8–6.2
Observational data: associations, not effects.
Further findings
Women with GDM: GCT threshold equal to prediabetes on postpartum HbA1c · 5 years
- GCT threshold
- 9.8 mmol/L
- 5-year diabetes risk (14.8-18.2)
- 16.5%
Original publication
The Glucose Challenge Test in Pregnancy Identifies Future Risk of Diabetes. J Clin Endocrinol Metab. Published 15 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →