Gestational diabetes & diabetes in pregnancy
Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years
Authors' conclusion
Maternal metformin treatment for GDM had no effects on adiposity, body composition, liver fat, or inflammation markers in prepubertal offspring compared to maternal insulin treatment but was associated with higher adiponectin concentration and lower leptin/adiponectin-ratio in boys.
Study context
- Population
- Prepubertal offspring at 9 years of age of 311 mothers randomized to metformin or insulin for gestational diabetes mellitus (GDM) (follow-up rate 55%)follow-up rate 55%
- Participants
- 172 participants
- Comparison
- Maternal metformin vs insulin for GDM
- Metforminn = 82
- Insulinn = 90reference
Primary result
As reported in the abstract
Adiposity, body composition, liver fat and inflammation markers · 9 years of age
- Serum markers of low-grade inflammation, visceral adipose tissue volume, total fat percentage and liver fat percentage were similar between the groups
Further findings
Serum adiponectin · 9 years of age · higher with Metformin
P = 0.016
Serum adiponectin, boys · 9 years of age · difference observed in boys only
P < 0.001
Median
| Outcome | Metformin | Insulin | P value |
|---|---|---|---|
| Leptin/adiponectin ratio, boys · 9 years of ageLower with Metformin | 0.30 | 0.75 | P = 0.016 |
Original publication
Metformin versus insulin for gestational diabetes: Adiposity variables and adipocytokines in offspring at age of 9 years. Diabetes Res Clin Pract. Published 16 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →