Gestational diabetes & diabetes in pregnancy
Predicting gestational diabetes mellitus risk at 11–13 weeks’ gestation: the role of extrachromosomal circular DNA
Authors' conclusion
Our study first demonstrats that eccDNAs are aberrantly produced in women who develop GDM, including PRDM16circle, which can predict GDM at an early stage of pregnancy, indicating its potential as a biomarker.
Study context
- Population
- Pregnant women at 11–13 weeks of gestation; discovery set of 5 later-GDM and 5 matched healthy controlsplus 5 vs 5 discovery set
- Participants
- 70 vs 70
- Comparison
- Plasma Extrachromosomal circular DNA (eccDNA) at 11–13 weeks in women who later developed gestational diabetes mellitus (GDM) vs normal glucose-tolerant (NGT) controls
- GDMn = 70
- NGTn = 70reference
- Outcome
- Diagnostic value of plasma PRDM16circle for GDM
- Follow-up
- 11-13 weeks of gestation
Methodological detailsCircle-seq discovery in matched pairs, quantitative PCR (qPCR) validation cohort
- Circle-seq discovery in matched pairs
- qPCR validation cohort
Performance
As reported in the abstract
| Test or model | AUC |
|---|---|
| PRDM16circle | 0.941 |
PRDM16circle
AUC0.941
- Significant diagnostic value of PRDM16circle (p < 0.001)
- AUC = 0.941
Further findings
Differentially detected eccDNAs (Circle-seq, future GDM vs controls) · 11-13 weeks of gestation
- Differentially detected eccDNAs
- 2217
- Increased in abundance
- 1289
- Decreased in abundance
- 928
- KEGG: eccDNA genes linked mainly to Rap1, MAPK, PI3K-Akt and insulin resistance pathways
Original publication
Predicting gestational diabetes mellitus risk at 11–13 weeks’ gestation: the role of extrachromosomal circular DNA. Cardiovasc Diabetol. Published 7 August 2024. doi:10.
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