Gestational diabetes & diabetes in pregnancy
Metabolic outcomes at 12 months postpartum among individuals with glucose intolerance in pregnancy
Authors' conclusion
Individuals with untreated glucose intolerance in pregnancy by the CC criteria have impaired β-cell function and significant metabolic abnormalities at 12 months postpartum similar to individuals with treated GDM, highlighting the need for ongoing preventive attention in this population to prevent type 2 diabetes later in life.
Study context
- Population
- Pregnant individuals randomised in GDM2 to gestational diabetes mellitus (GDM) testing by International Association of Diabetes and Pregnancy Study Group (IADPSG) or Carpenter-Coustan (CC) criteria, followed to 12 months postpartumseen at 12 months
- Participants
- 407 individuals
- Comparison
- Untreated glucose intolerance and treated GDM vs normal glucose tolerance
- Untreated glucose intolerancen = 49
- Treated GDMn = 53
Methodological detailsplanned 12-month postpartum follow-up
- Planned 12-month postpartum follow-up
Primary result
As reported in the abstract
Insulin sensitivity, β-cell function, dyslipidemia, leptin and adiponectin · during pregnancy and 12 months postpartum
- Significant differences in insulin sensitivity, β-cell function, dyslipidemia, and alterations in leptin and adiponectin with both untreated glucose intolerance and treated GDM vs normal glucose testing
Original publication
Metabolic outcomes at 12 months postpartum among individuals with glucose intolerance in pregnancy. J Clin Endocrinol Metab. Published 2 February 2026. doi:10.
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