Gestational diabetes & diabetes in pregnancy
Glucose tolerance two years after gestational diabetes classified by old Swedish or new WHO diagnostic criteria
Authors' conclusion
The lower glucose cut-offs during pregnancy resulted in lower postpartum incidence of T2D, irrespective of BMI. Fat-free-mass emerged as a key determinant in glucose levels across BMI categories, while lower beta-cell function played a significant role in normal-weight women.
Study context
- Population
- Women in the PREvention of PostPartum (PREPP) diabetes study with GDM, stratified by BMI, Sweden
- Participants
- 93 / 174 / 88
- Exposure
- GDM by EASD 1991 criteria vs GDM by WHO 2013 criteria only
- GDMOLDn = 93
- GDMWHOn = 174reference
- Controlsn = 88
- Outcome
- Prediabetes/T2D incidence
- Follow-up
- Two years postpartum
Methodological detailsBMI-stratified, BMI-matched normoglycemic controls
- BMI-stratified
- BMI-matched normoglycemic controls
Main finding
As reported in the abstract
Postpartum incidence of T2D
- Higher postpartum incidence of T2D in GDMOLD vs GDMWHO
- GDMOLD vs GDMWHO: P < 0.001
Observational data: associations, not effects.
Further findings
Glucose levels and body composition
- Despite similar BMI, GDMOLD had higher fasting and oral glucose tolerance tests (OGTT) glucose, lower fat-free-mass and hip circumference vs GDMWHO
Normal-weight women
- Both GDM groups had higher HOMA-IR and lower fat-free-mass vs controls; GDMOLD also had lower HOMA-β, slower insulin release during OGTT and worse glucose tolerance than GDMWHO
Obese women
- Main differences were lower fat-free-mass and hip circumference in GDMOLD
Original publication
Glucose tolerance two years after gestational diabetes classified by old Swedish or new WHO diagnostic criteria. Diabetes Res Clin Pract. Published 20 August 2024. doi:10.
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