Gestational diabetes & diabetes in pregnancy
The One‐Hour Oral Glucose Tolerance Test to Predict Glucose Intolerance Postpartum in Women With Prior Gestational Diabetes
Authors' conclusion
In women with a recent history of GDM and subsequent prediabetes, a 1-h glucose value ≥ 8.6 mmol/L in early postpartum was associated with an increased risk for future type 2 diabetes, greater insulin resistance and impaired β-cell function, supporting its potential value as an early marker of metabolic risk.
Study context
- Population
- Women with prediabetes after GDM (WHO 2013 criteria) in a trial of a mobile-based lifestyle intervention early postpartum
- Participants
- 1,193 women
- Comparison
- 1-h glucose ≥ 8.6 mmol/L vs < 8.6 mmol/L at 3 months postpartum
- Primary endpoint
- Whether 1-h glucose on the postpartum OGTT predicts dysglycaemia and metabolic changes
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Dysglycaemia by 2-h OGTT
28.0%
334/1193
Dysglycaemia by 1-h glucose
34.2%
408/1193
Of 166 women with baseline prediabetes by 2-h OGTT, 1-h glucose ≥ 8.6 mmol/L
63.9%
106
Further findings
Outcomes at 1 year postpartum (repeat OGTT subgroup) · dysglycaemia · per_group values: dysglycaemia
P = 0.010
| Outcome | P value |
|---|---|
| Outcomes at 1 year postpartum (repeat OGTT subgroup)T2D: all 8 (7.3%) diagnoses in ≥ 8.6 mmol/L · per_group values: dysglycaemia | P = 0.036 |
| Outcomes at 1 year postpartum (repeat OGTT subgroup)Greater β-cell impairment (lower ISSI-2) with ≥ 8.6 mmol/L · per_group values: dysglycaemia | P = 0.001 |
| Outcomes at 1 year postpartum (repeat OGTT subgroup)Greater insulin resistance (lower Matsuda) with ≥ 8.6 mmol/L · per_group values: dysglycaemia | P = 0.049 |
Original publication
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