Gestational diabetes & diabetes in pregnancy
Mendelian randomization analysis reveals causal effects of blood lipidome on gestational diabetes mellitus
Authors' conclusion
Genetically predicted elevated TG_by_PG are causally associated with an increased risk of GDM. Side-effect profiles indicate that TG_by_PG might be a target for GDM prevention, though caution is advised due to potential adverse effects on other conditions.
Study context
- Population
- Summary statistics for 295 lipid metabolites and gestational diabetes mellitus (GDM)295 lipid metabolites
- Comparison
- Genetically predicted lipid metabolites and GDM
- Outcome
- Causal relationship between lipid metabolites and GDM
Methodological detailssummary statistics, sensitivity, validation and reverse Mendelian randomization (MR) analyses, phenome-wide MR (Phe-MR), 29 metabolites had ≥3 instrumental variables suitable for sensitivity analyses
- Summary statistics
- Sensitivity, validation and reverse MR analyses
- Phenome-wide MR (Phe-MR)
- 29 metabolites had ≥3 instrumental variables suitable for sensitivity analyses
Performance
As reported in the abstract
GDM per triglycerides to phosphoglycerides ratio (TG_by_PG)
TG_by_PG: Inverse variance weighted (IVW) OR (95% CI 1.415-3.257), P = 3.26e-4
2.147
Further findings
GDM per palmitoyl sphingomyelin (d18:1/16:0) (PSM(d18:1/16:0))
- IVW OR (95% CI 0.583-0.956), P = 0.021
- 0.747
- Suggestive potential biomarker, conventional cut-off P-value of 0.05
GDM per triglycerides in very small VLDL (XS_VLDL_TG)
- IVW OR (95% CI 1.197-5.215), P = 0.015
- 2.948
- Suggestive potential biomarker, conventional cut-off P-value of 0.05
Safety
Phe-MR side effects of lowering TG_by_PG
- Diseases with detrimental effects
- 2
- Diseases with advantageous effects
- 13
Original publication
Mendelian randomization analysis reveals causal effects of blood lipidome on gestational diabetes mellitus. Cardiovasc Diabetol. Published 11 September 2024. doi:10.
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