Gestational diabetes & diabetes in pregnancy
Comparing the different phenotypes of diabetes in pregnancy: Are outcomes worse for women with young-onset type 2 diabetes compared to type 1 diabetes?
Authors' conclusion
In pregnancy, YT2DM appears to be the lower-risk cohort compared to T1DM despite higher obesity rates. Gaps in achieving glycaemic targets exist for both subtypes but particularly for T1DM. The relative impact of increasing BMI in pregnancies affected by T1DM requires further elucidation.
Study context
- Population
- Singleton pregnancies affected by pregestational T1D or young-onset T2D diagnosed at < 40 years, single centre, 2010–2019
- Participants
- 259 singleton pregnancies
- Exposure
- Young-onset T2D vs T1D in pregnancy
- Outcome
- Preterm delivery, large for gestational age (LGA) infants and pre-eclampsia
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Preterm delivery, LGA infants, pre-eclampsia
- Significantly lower rate of large for gestational age (LGA) infants in YT2DM vs T1DM
- p < 0.05
Observational data: associations, not effects.
Further findings
NICU admission, neonatal hypoglycaemia, neonatal respiratory distress
- Significantly lower rates of NICU admission, neonatal hypoglycaemia and neonatal respiratory distress in YT2DM vs T1DM
- P < 0.05 for all
Second/third trimester mean HbA1c
- Significantly higher in T1DM
Baseline characteristics
- Overweight/obesity in T1DM
- 46 %
- YT2DM older, more obesity, greater apparent sociodemographic disadvantage, lower pregnancy preparedness
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparing the different phenotypes of diabetes in pregnancy: Are outcomes worse for women with young-onset type 2 diabetes compared to type 1 diabetes? Diabetes Res Clin Pract. Published 6 September 2024. doi:10.
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